The Lions travel to Coca Cola Park (formerly known as Ellis Park) looking for the win that their performances in the opening two rubbers have so thoroughly deserved.
Skipper Paul O'Connell and his men will have to put the disappointment of last weekend's last-minute loss behind them as they look to finish with a flourish in their final game on tour.
It would be churlish to say that pride is all that is left at stake as the Lions have already more than restored such an emotion into the red shirt with their brave performances in Durban and Pretoria.
Instead, Saturday's last clash with the Springboks will be about one thing as far as the Lions are concerned: winning.
Britain and Ireland's elite have now lost their last seven Tests against the three southern hemisphere giants and a win in Jo'burg would put an end to that frustrating run. Victory would also see the Lions leave an even greater impression on the rugby world. It may not have been quite the one they were looking for, but it would least act as another reminder that the Lions are well and truly here to stay.
Injuries have forced Lions head coach Ian McGeechan into a number of changes to his starting XV, with the impressive centre pairing of Brian O'Driscoll and Jamie Roberts and Welsh props Adam Jones and Gethin Jenkins all ruled out following incidents in the second-half in Pretoria last weekend.
McGeechan makes seven personnel changes and one positional switch for the last encounter of the tour as the Lions look to avoid the unwanted title of the first Lions side to be whitewashed on South African soil.
Shane Williams, Ugo Monye, Riki Flutey, Martyn Williams, Joe Worsley, Andrew Sheridan and Phil Vickery all come into the side, while Tommy Bowe moves from the wing to outside centre after O'Driscoll flew home to Ireland with concussion earlier this week.
Martyn Williams will be starting his first Test for the Lions having been a replacement earlier in the series and on his two previous tours of Australia and New Zealand. The Cardiff Blues and Wales openside was named in the matchday squad for all three games against the Wallabies eight years ago but failed to get any game time. He then made the bench for the second and third Tests against the All Blacks four years later but only saw a few minutes of action at the end of the third encounter. In 2009, Williams has come off the bench in both Tests to date and now finally has his chance to impress from the opening whistle in what, at the age of 33, is likely to be his last appearance in Lions colours.
Flutey and Worsley will both be winning their first Lions Test caps having not been involved in the squads for the first two internationals, while halfbacks Stephen Jones and Mike Phillips, No8 Jamie Heaslip and skipper Paul O'Connell are the only players in line for their third successive Test start in 2009.
James Hook and John Hayes both step up to the bench, from where they could join Flutey and Worsley in making their Test debuts for Britain and Ireland's elite.
While the Lions have changed more than half their starting XV for the third rubber, the Springboks have gone even further by disposing of two thirds of their side that began the second Test.
Only John Smit, Beast Mtawarira, Victor Matfield, Juan Smith and Fourie du Preez keep their places in the South African XV as head coach Peter de Villiers turns his eye towards this summer's Tri Nations and the 2011 World Cup.
De Villiers hands a debut to Bulls full back Zane Kirchner, who will be hoping for a better performance than when he last faced the Lions on June 23. Kirchner is seen by many as one of the hottest prospects in South African rugby yet his poor clearance kick gifted the mid-week Lions a try during the 13-13 draw in Cape Town between the first and second Tests.
Last week's South African hero Morne Steyn is rewarded for his match-winning second-half display with his first start for his country, while Jaque Fourie will be asked for more of the same after he scored a stunning individual try having come off the bench in Pretoria.
Fellow tryscorers Bryan Habana and JP Pietersen both drop out of the squad, but instead of suffering a drop in pace out wide the Boks have selected an arguably even quicker pairing in Jongi Nokwe and Odwa Ndungane.
Wynard Olivier gets his chance alongside Fourie having been a stand-out performer during the Bulls' Super 14 triumph earlier this year, while club-mate Chiliboy Ralepelle is promoted to the starting line up after being among the replacements last time out.
With Bakkies Botha suspended and Andries Bekker injured, there are call ups for two second rows at opposite ends of their international careers. World Cup winner and veteran Sharks skipper Johann Muller starts alongside Victor Matfield, while his uncapped Sharks team-mate Steven Sykes is named on the bench.
Schalk Burger's eight-week ban for eye gouging leads to a recall for Heinrich Brussow, a tryscorer in the first Test in Durban, with Ryan Kankowski given a chance to challenge for Pierre Spies' place at No8.
In total, the Boks make 10 changes from Pretoria, although de Villiers insists that they will still be taking Saturday's encounter seriously. His decision to alter so much of a winning squad may suggest that his attentions are elsewhere but de Villiers knows that a 3-0 series victory would enhance his own reputation following some recent criticism from both at home and abroad.
For the Lions, a 3-0 reverse would be the worst-case scenario on what has been a hugely successful tour. McGeechan's men fell just short in Durban and Pretoria but a win of any sorts in Jo'burg would ensure the tour ends on a real high.