The squad includes 11 uncapped players, including recent rugby league converts Kyle Eastmond and Joel Tomkins. Five players are 21 or under, the youngest of whom is London Wasps No.8 Billy Vunipola, whose brother Mako is in the British & Irish Lions squad.
England will take on the Barbarians at Twickenham Stadium on 26 May before playing a CONSUR XV, representing the South American nations, in Montevideo, Uruguay, on 2 June. They will then play Tests against Argentina in Salta on 8 June and Buenos Aires on 15 June 15.
"We're really looking forward to this tour and we've selected a young and exciting side which I'm sure will do the country proud in a tough series of matches," said England Head Coach Stuart Lancaster.
"The key principles in selection were threefold: first and foremost to win the games but also to develop strength in depth and more options in certain positions, and to give one or two players a physical and mental break.
"We feel we've got the balance right and have given places to a number of players who have shone in the Aviva Premiership this season, one or two who have been on the fringes for a while, and several players who have been involved over the last year or so. This is everyone's chance to step up.
"Tom Wood will captain the side and I am sure he will do a fantastic job, as he has the respect of all the players and management and we are looking forward to other leaders developing in the absence of some senior players.
"A few are being rested after a hard campaign but they will, of course, be considered by the British & Irish Lions should they be required."
England Summer Tour Squad
Mike Brown (Harlequins), Freddie Burns (Gloucester), Lee Dickson (Northampton Saints),
Kyle Eastmond (Bath), Ben Foden (Northampton Saints), Alex Goode (Saracens), Jonathan Joseph (London Irish), Jonny May (Gloucester), David Strettle (Saracens), Joel Tomkins (Saracens), Billy Twelvetrees (Gloucester), Christian Wade (London Wasps), Richard Wigglesworth (Saracens), Marland Yarde (London Irish)
Dave Attwood (Bath), Rob Buchanan (Harlequins), Calum Clark (Northampton Saints), Alex Corbisiero (London Irish), Paul Doran Jones (Northampton Saints), Tom Johnson (Exeter Chiefs), Matt Kvesic (Worcester Warriors), Joe Launchbury (London Wasps), Courtney Lawes (Northampton Saints), Joe Marler (Harlequins), Ben Morgan (Gloucester), David Paice (London Irish), Ed Slater (Leicester Tigers), Henry Thomas (Sale Sharks), Billy Vunipola (London Wasps), Rob Webber (Bath), David Wilson (Bath), Tom Wood (Northampton Saints, captain)