Samo was in the thick of the action in Canberra in 2001 as a last-minute try from Austin Healy and Matt Dawson's nerveless conversion saw The Lions edge a thrilling encounter 30-28.
The 36-year-old Australian international admits the memories of that defeat are still raw despite the passing of time and he is desperate to make amends when he gets his second shot at history in Brisbane.
"I never thought I'd be playing The Lions again. I played against them in 2001 but never believed I'd play them 12 years later," said Samo.
"I played against them with the Brumbies last time when they scored on the bell and won the game. We had pretty much won that game, so 12 years after I'm playing for revenge.
"You lose some games late in Super Rugby but you get a second chance. You don't normally get that with The Lions. I have had to wait 12 years for that.
"If I can come off the bench, do what I do and play well, hopefully things can go well. It would be massive to win the game for me and the whole team.
"I'm looking forward to it and I know the rest of the boys are looking forward to it as well."
Samo will become part of a select group of men to have faced The Lions on more than one tour and is likely to be the only Australian to line up against the visitors in both 2001 and 2013.
Australia's 116-cap lock forward, Nathan Sharpe, came close to matching the feat before announcing that his country's final Test before the Lions series would be his last, while veteran flanker George Smith looks set to miss out on a national recall due to a knee injury.
It's an achievement that isn't lost on Samo, who insists it will be something he will remember long after his playing days are over. And if the achievement can be accompanied by a surprise victory then Samo will have even more reason to celebrate his remarkable journey.
"Most of the guys never get a chance to play The Lions and those that do only usually get one chance. I'm lucky enough to get two chances. It's a massive, massive honour," added Samo.
"When I look back at my career, I will be able to tell my kids that I played The Lions twice.
"The Lions will have been watching our Super XV games and they will know that we are not just turning up to play - we will be turning up to win.
"For The Lions, it's one of their biggest games before the Test matches. They want to win every game before the Test series, but we've got nothing to lose.
"Our (current) Wallabies aren't playing but it's a big, big game for us. It's a great opportunity and we're all looking forward to it. We can't wait."
Did you know?
World Cup winning captain John Smit was the last man to play against The Lions on more than one tour. The Springbok front rower was a replacement for the Natal Sharks in 1997 before skippering his country to glory in a thrilling Test series in 2009.
Legendary All Black lock Colin Meads played 14 times against the tourists in New Zealand in 1959, 1966 and 1971 but that isn't the record number of appearances against The Lions.
That honour belongs to Barry Heatlie, who featured in South Africa six times in 1891, five times in 1896 and five times in 1903 before captaining Argentina against the 1910 Lions in the last of his 17 outings.