The Wales and Lions centre has recovered from the shoulder knock he suffered in the New Year Magners League victory over the Cardiff Blues and is all set to return to the Ospreys midfield.
"Gavin is fine, although we have lost Sonny Parker for a couple of weeks with a damaged rib," confirmed Ospreys coach Sean Holley.
"That means the selection problems I might have had at centre won't be as bad because Andrew Bishop is playing so well at the moment."
Henson has been in sparkling form since returning late this season after an operation on his ankle. He scored two tries from full back against the Dragons and has also figured at centre.
He will be looking to impress Wales coach Warren Gatland over the next two weeks as the Ospreys got into battle with Perpignan and Leicester Tigers to see which team will emerge on top of Pool 3 in Europe.