Former England international Hill - a veteran of two Lions tours - has been named in the starting XV to play Bristol in the unfamiliar surroundings of the MK Stadium in Milton Keynes.
Saracens have been relocated because their usual home of Vicarage Road is unavailable due to Watford's involvement in the Coca-Cola Championship play-offs.
"Milton Keynes is not the venue where I would have expected to complete my playing days," said Hill.
"But wherever the venue, I will be sharing the day with my team-mates, friends, family and the Saracens fans and that's how I want it."
Hill, who won the World Cup with England in 2003, is widely considered to be one of the best players of his generation.