If confirmed, the match would give Lions coach Ian McGeechan the opportunity to watch all four Home Unions in action against the Springboks ahead of the 2009 summer tour.
The proposed fixture would also be new Ireland coach Declan Kidney's first game in charge of his country, with forwards coach Gert Smal beginning his introduction to Irish rugby against his South African compatriots.
Confirmed autumn fixtures involving South Africa
November 8 Wales vs South Africa
November 15 Scotland vs South Africa
November 22 England vs South Africa
Ireland vs South Africa is currently awaiting approval from the IRB