Lewsey, who will line-up on the wing at Murrayfield, is anxious that the current RBS 6 Nations and world champions do not come unstuck against their neighbours.
He said: "If you look at England's history at Murrayfield it's littered with upsets.
Complacency is a word that does not enter the vocabulary of this squad any more due to what's happened in the past.
"We've learnt the hard way, which is the best way to learn. Basically it means we'll go to Edinburgh and treat them with the utmost respect. Scotland will be looking to rectify last weekend's defeat in Cardiff.
"What people seem to forget is that the last time England won a World Cup the first side to beat them was the Auld Enemy - and that was at Wembley."
England coach Sir Clive Woodward was forced to make one change to his starting line-up, bringing in Chris Jones after an injury to Wasps flanker Joe Worsley.
The 6ft 6in Sale Sharks forward made his debut as a second-half substitute against Italy, scoring the last of seven tries.
His place among the substitutes is taken by Sharks team-mate Alex Sanderson.
Scotland coach Matt Williams named two changes in his side following their 23-10 defeat in Wales.
Williams has promoted Edinburgh's centre/wing Simon Webster and Sale Sharks' lock/back-row forward Jason White to his starting XV.
Edinburgh's Allister Hogg, who made his debut in Cardiff, and Glasgow's Andrew Henderson have made way.
"We want to put on a performance that everyone will be proud of," Williams told official SRU website www.scottishrugby.org.
"The team today is very young and probably the most inexperienced side in the top 10 world rankings just now.
"Last week we gave out four new caps and three others were in their first ever 6 Nations match so almost half the team have never played 6 Nations rugby before which is quite extraordinary.
"Taking on the world champions is a great opportunity for us to test ourselves against the best."