"We're delighted with the win. Argentina have always been a difficult team to come up against, especially for the Irish," said Bowe, who starred for the Lions just over a year ago.
"To come away with our biggest winning margin against them, in the final game of the year, is a great positive going through to the Six Nations.
"It does make up for those losses in a way. Obviously there's still that disappointment from the two-point loss to South Africa. We picked our game up against New Zealand but we leaked a couple of soft tries.
"But I think we can hold our heads up - it's been a good end to the campaign, although there's a lot to work on."
Ireland scored two tries on Sunday afternoon and had another ruled out by the television match official, all of them through 2009 Lions squad members.
Stephen Ferris crossed for the first after good work from Bowe and fellow Lion Jamie Heaslip, while Gordon D'Arcy crossed in injury time after Keith Earls had been denied via the video reply.
"Whenever we've had a fairly dry ball we've shown we're able to throw the ball around," added Bowe.
"We've got plenty of players who are willing to play good rugby but the opportunity doesn't present itself too often. When we get the chance we're able to cut teams open. We've scored a few good tries and, hopefully, we can build on that.
"Ferris started this campaign with no tries for Ireland but now he's got two so he's hard man to listen to at the moment!"