No fewer than nine of the starting line up, and 15 of the 22, have played against the Lions already on tour and revenge will be very much on their minds.
Everyone who faced the tourists tasted defeat, although Emerging Boks coach Dick Muir has promised the Lions a tough time.
"We are all working towards the goal of South Africa winning the test series against the Lions and it would be great if we could make it two wins in a row after that victory by the Springboks in the first Test in Durban," said Muir.
"The Lions went into the Test having won six out of six and they came very close in Durban. It is going to be a big forward battle again and this game is really going to test our players.
"I'm looking forward to seeing the back row combination playing together and we have an exciting half-back unit who play together regularly with the Golden Lions.
"This team is probably on a par with the Southern Kings side the Lions faced, although we won't have the same level of experience. The Kings really got stuck into the Lions and we will take that same attitude into the game."
Blue Bulls full back Zane Kirchner gets his big chance to show he should have been included in the Springboks squad after helping the Bulls to win the Super 14 title, while Cheetahs prop Wiaan du Preez will be looking to poach another try against the tourists after scoring one against them in Bloemfontein.
The players in the team who have yet to face the Lions are Kirchner, Earl Rose, skipper Dewald Potgeiter, Wilhelm Steenkamp, Werner Kruger and Bandise Maku. Among the replacements, Heini Adams is the only member of the replacements not to have faced the Lions.
Emerging Springboks: Zane Kirchner (Blue Bulls); Luzuko Vulindlu (Sharks), Deon van Rensburg (Leopards), Morgan Newman (Western Province), Bjorn Basson (Griquas); Earl Rose (Golden Lions), Jano vermaak (Golden Lions); Wian du Preez (Free State Cheetahs), Bandise Maku (Blue Bulls), Werner Kruger (Blue Bulls), Steven Sykes (Sharks), Wilhelm Steenkamp (Blue Bulls), Jean Deysel (Sharks), Duane Vermeulen (Western Province).
Replacements: Tiaan Liebenberg (Western Province), Patric Cilliers (Sharks), Franco van der Merwe (Golden Lions), Jacques Botes (Sharks), Heini Adams (Blue Bulls), Willem de Waal (Western Province), Danwel Demas (Free State Cheetahs)