The Free State Cheetahs back row ace was drafted into the world champions' side to meet Paul O'Connell's men when Schalk Burger was ruled out with injury.
It means the Lions will have to find the means to stop Brussow from wrecking their dreams at the breakdown in the same way he did in the 26-24 win by the Lions in Bloemfontein.
It has been a testing few weeks for Brussow who a week before being drafted into the Springbok squad was sitting an economics exam at university.
"No prizes for guessing which test I would prefer to take. It has been from hell to heaven in the space of a week," said Brussow.
The 22-year-old caused no end of concerns for the Lions as he helped the Cheetahs hit back from a 20-0 deficit to almost steal the game. Largely through his efforts the Lions turned over the ball 19 times during the game.
"I'm not sure what the Lions will be thinking about my inclusion in the team, but hopefully they will remember Bloemfontein and that will give us a mental advantage," he said.
"When they take a good look at the footage of that game they will see that I was perfectly legal. I am a small guy and that means I can get into places the big guys can't.
"The fetcher has to tread as fine line - you have to be bold, but you have to be careful. You walk a tightrope because you may give away three points if you transgress."
New Zealand referee Bryce Lawrence will be the man charged with ruling the breakdown area and Brussow knows him well from the Super 14. he also knows the Lions are bound to raise some issues with the Kiwi official about what happened to them in Bloemfontein.
But none of that is going to put off the youngster who intends to make the most of his shock opportunity after originally being left out of the Springbok squad.
"It is a huge opportunity and responsibility. Slowing down the ball is one of the keys to success in Test rugby because it gives your defensive line more time to get organised," he added.
"They have a lot of really good, in-form back line players like Brian O'Driscoll and Jamie Roberts, so we don't want them getting too much ball through quick recycles. At the same time, if I can turn over their ball we have a superb back line that is very dangerous on the counter attack.
"If I can give the guys an opportunity on both counts I will have done my job. I have confidence in my ability to deliver."
If he does deliver, then the Lions could be in trouble.