Sean Lamont returns on the right wing in place of Max Evans, while Chris Cusiter gets his first start on tour by swapping places with Mike Blair. The Scots are chasing their first clean sweep on a summer tour in the southern hemispheres having already beaten Australia and Fiji.
"That's something we are striving for. We have to focus on winning each Test and we go into Saturday with confidence that we can take on a strong Samoan side," said head coach Andy Robinson.
"You just have to look at what happened two years ago when we were at home. On the back of beating South Africa, and in conditions that were utterly alien for the Samoans, we were drawing 16 all with one minute to go at Pittodrie and we were lucky enough to get a penalty to win the game."
The bench will be confirmed later this week. Meanwhile, South African referee Jaco Peyper will control his third successive Scotland match having been called up by the IRB when the original referee Chris Pollock (New Zealand) withdrew on account of injury.
15 Stuart Hogg (Glasgow Warriors)
14 Sean Lamont (Glasgow Warriors)
13 Nick De Luca (Edinburgh Rugby)
12 Matt Scott (Edinburgh Rugby)
11 Tim Visser (Edinburgh Rugby)
10 Greig Laidlaw (Edinburgh Rugby)
9 Chris Cusiter (Glasgow Warriors)
1 Ryan Grant (Glasgow Warriors)
2 Ross Ford (Edinburgh Rugby, captain)
3 Euan Murray (Newcastle Falcons)
4 Richie Gray (Sale Sharks)
5 Alastair Kellock (Glasgow Warriors)
6 Alasdair Strokosch (Perpignan)
7 Ross Rennie (Edinburgh Rugby)
8 Richie Vernon (Sale Sharks)