The only change is on the bench where Wasps flanker Jonny O'Connor replaces Munster's Mick O'Driscoll, having recovered from a groin injury.
Success at Twickenham would hand Ireland their second Triple Crown in three years while they also have a chance of winning the championship outright.
Ireland team to play England in the Six Nations Championship at Twickenham on Saturday:
G Murphy (Leicester); S Horgan (Leinster), B O'Driscoll (Leinster, capt), G D'Arcy (Leinster), A Trimble (Ulster); R O'Gara (Munster), P Stringer (Munster); M Horan (Munster), J Flannery (Munster), J Hayes (Munster), M O'Kelly (Leinster), P O'Connell (Munster), S Easterby (Llanelli), D Wallace (Munster), D Leamy (Munster).
Replacements: R Best (Ulster), S Best (Ulster), D O'Callaghan (Munster), J O'Connor (Wasps), E Reddan (Wasps), D Humphreys (Ulster), G Dempsey (Leinster)