The Tigers head to Twickenham for stage one of a possible treble, with a Heineken Cup semi-final and Guinness Premiership title play-off also looming.
Welsh region the Ospreys stand between Leicester and a first piece of major silverware since they retained the Heineken Cup in 2002.
And England international fly-half Goode, who starts on the bench as cover for Paul Burke, has underlined his side's determined mood.
He said: "Winning this trophy would mean a lot to us. We haven't won a trophy for five years and that is very frustrating. We've got a great chance to put that to bed now.
"We've lost the last two Premiership finals and a couple of big European games, but we've shown we have the big-match mentality in our last two games in this season's Heineken Cup against Munster and Stade Francais.
"We know the Ospreys are a very good team, but we will beat them if we perform to the best of our ability."
Goode will be joined on replacement duty by the likes of Geordan Murphy and Louis Deacon as Tigers head coach Pat Howard recognises the bigger picture of his team facing a gruelling four games in 14 days, starting on Sunday.
Martin Corry returns to lead Leicester after sitting out last Friday's one-point Premiership win against Sale Sharks.
Corry's England colleagues Harry Ellis, George Chuter and Julian White also feature, while Burke - who has started three of Tigers' EDF games this season - wears the number 10 shirt.
Elsewhere, Italy prop Martin Castrogiovanni replaces the suspended Marcos Ayerza, and there is also an opportunity for highly-rated blindside flanker Tom Croft to impress.
The Ospreys are without the injured Gavin Henson - he is unlikely to play again this season - but a powerful line-up includes Wales internationals such as James Hook, Shane Williams, Sonny Parker, Duncan Jones, Ryan Jones and Jonathan Thomas, plus former New Zealand scrum-half Justin Marshall.
Ospreys head coach Lyn Jones said: "Last season's Heineken Cup fixtures against Leicester [Ospreys lost both games] taught us what it takes to be successful at this level.
"Leicester have turned their season around since beating Munster away in January, and they are now playing with the confidence of old.
"We are looking to set the record straight by wining this competition after losing two tight matches against Leicester last season."