Argentina had fullback Federico Serra and Juan Fernandez Lobbe to thanks for the victory as they got two tries each while Felipe Cotempomi top-scord with 25 points.
Marcelo Bosch, Martin Gaitan, Martin Scelzo, Gonzalo Longo and Manuel Contepomi scored one try each to complete the scoring for the Pumas.
Cristobal Berti got the only two tries for Chile.
"This match served to pick up rhythm and in spite of the level of the rivals, it was a good test," said Juan Martin Hernandez after the game at CASI stadium.
Pumas will continue training until August 13 when they will fly to Europe.
On August 18, Argentina will visit Wales in Cardiff and seven days later they will play against a local team in Belgium.