Tindall's midfield excellence steered Gloucester to a resounding 44-24 Guinness Premiership victory over Sale Sharks at Kingsholm.
Gloucester moved third in the table as a result, while Tindall's performance would suggest he has to feature at Twickenham in seven days' time.
Ryan said: "Mike has been outstanding for us, and he brings so much more than the physical side to his game that everyone writes about.
"He is freeing the game up for us, and he has been in good form for a number of weeks now.
"Without him, we are a completely different back-line, and there is no doubt we missed him at the start of the season when he was injured."
Tindall was at the heart of Gloucester's attacking game that produced five tries, including a thrilling opening touchdown after just 85 seconds for fly-half Ryan Lamb.
Tindall's fellow England candidate Iain Balshaw also got in on the act with a solo score as Gloucester effectively had the game wrapped up inside 45 minutes.
Sale, to their credit, kept battling away and claimed three tries of their own, but an injury toll that has run well into double figures continues to undermine their season.
Brighter news could be ahead on the injury front with England prop Andrew Sheridan possibly featuring before too much longer.
Sheridan has not played since suffering an ankle injury during England's Autumn Tests and Sale will not give up on the play-off chase even though the odds continue to be stacked against them.