The World Cup winner has not played for England this season but a new centre partnership is likely to be unveiled on Monday with Tindall and former Great Britain rugby league captain Andy Farrell teaming up against opening Six Nations Championship opponents Scotland next Saturday.
England will go into the Six Nations campaign on the back of a dismal sequence - eight defeats in their last nine Tests.
But Gloucester star Tindall detects a positive outlook under new head coach Brian Ashton.
The former Bath boss oversaw a three-day Twickenham training camp last week, and Tindall said: "It was just completely different.
"The Tuesday morning session, for instance, was one of the best England sessions I've done in years. It was fun and it challenged the players, which is the big thing.
"The problem is when you have a losing streak and a disappointing year, with each training session the pressure gets a little bit more, but it actually feels as if there is a clean slate now.
"There has got to be a mood of optimism. If you look at how Wasps, Leicester and ourselves went in the Heineken Cup last week, we've got good players - a lot of good players.
"I am generally happy with how things are going. I am enjoying getting the ball in my hands and getting a good off-load game going.
"I just feel really good at the moment. I had an excellent pre-season and I haven't got any injury niggles so, touching every piece of wood around, hopefully it will stay that way."