Having secured a 2-1 series victory over the Lions earlier this summer, the World Champions are set to take on France in Toulouse on November 13, Italy in Udine on November 21 and Grand Slam winners Ireland a week later in Dublin on November 28.
The Boks will also play two games against club sides in the form Guinness Premiership outfits Leicester Tigers and Saracens on Friday, November 6 and Tuesday, November 17 respectively.
And head coach Peter de Villiers has made it clear that he will not be sending a weakened squad to the northern hemisphere.
"At this moment, we are not looking to rest anyone," said de Villiers, who will name a 37-man squad after the Currie Cup Final which takes place on October 31.
Apart from hooker Chiliboy Ralepelle who has been told to rest for a couple of weeks due to a broken foot, de Villiers has no major injury worries for the end-of-year tour.
De Villiers has also welcomed the addition of the clash with Sarries to his side's schedule, adding that the Wembley fixture could be yet another highpoint of an already memorable season.
"We have enjoyed a fantastic year so far, and this match - against an in-form club team at one of the great stadiums in the world - will certainly become yet another highlight in this memorable season.
"Overseas tours always provide us with an opportunity to expose our emerging young talents to the international game and this will be a fantastic platform through which to do that. We expect Saracens to be tough but also believe in the abilities of our squad."
The final game of the three-match tour could see as many as 12 2009 Lions given another chance to get one over the Boks at Croke Park, five months after South Africa broke British and Irish hearts in Pretoria.
Ireland's Tommy Bowe, Luke Fitzgerald, Jamie Heaslip, John Hayes, Rob Kearney, Donncha O'Callaghan, Paul O'Connell, Brian O'Driscoll, Ronan O'Gara and David Wallace all appeared in the three-match Test series against the Boks, while Keith Earls and Stephen Ferris featured on the tour of the Republic but missed out on the chance to face the world's No1 team.
Jerry Flannery, Alan Quinlan and Tomas O'Leary could also be given a chance to tackle the South Africans, having been cruelly denied the opportunity to tour with the Lions after injury or suspension forced them to withdraw from Ian McGeechan's original tour party prior to departure.