Coach Eddie O'Sullivan has recalled lock Gary Longwell and flanker Victor Costello, who both missed the 25-24 victory over Wales in Cardiff five days ago.
Leinster second row Leo Cullen drops out for Longwell - while Munster's Alan Quinlan misses out, with Costello coming in.
O'Sullivan has otherwise said same again, as Ireland target the RBS 6 Nations title and their first championship clean sweep since 1948.
Ireland team: G Murphy (Leicester), J Bishop (London Irish), B O'Driscoll (Leinster, captain), K Maggs (Bath), D Hickie (Leinster); D Humphreys (Ulster), P Stringer (Munster); M Horan (Munster), S Byrne (Leinster), J Hayes (Munster), G Longwell (Ulster), M O'Kelly (Leinster), V Costello (Leinster), K Gleeson (Leinster), A Foley (Munster).
Replacements: F Sheahan (Munster), J Fitzpatrick (Ulster), P O'Connell (Munster), A Quinlan (Munster), G Easterby (Llanelli), R O'Gara (Munster), G Dempsey (Leinster).