England have arrived in the Welsh capital as overwhelming favourites to pile the agony on a Welsh rugby nation still reeling from last weekend's shock defeat in Italy.
Woodward though, who has painful memories of losing games that England were expected to win, is taking nothing for granted.
"We are clearly favourites, based on the games last weekend, but upsets happen and that is the beauty of sport," he said.
"It is 15 against 15. We've seen Llanelli playing, and they are a match and more for any team. The Welsh team is in a bit of a corner. And we are expecting a physical full-on game.
"The more that England are favourites, the more the pressure is on you. If Wales play with a passion that they know they can, then England have got to be at their best.
"The ramifications of England losing this game are huge. The players know that, and we are under immense pressure, but that is what playing for England is about."