O'Driscoll, a certainty for Sir Clive Woodward's squad for the forthcoming tour of New Zealand, made his return to the Ireland side following a hamstring injury with the match-winning try that ensured his country's Grand Slam dream remains intact.
The centre scored after being released by full-back Geordan Murphy in the tightest of spaces before skipping within a hair's breadth of the touchline and crossing over.
"We are delighted, we felt if we performed well then we would win but with England also having played very well it makes it all the sweeter," O'Driscoll said after the game.
"As for my try it was a move we had worked on all week.
"There was a bit of magic from Geordan Murphy and it was a great break from Denis Hickie.
"The lads were complaining about the time I took to put the ball down at the end but really it was an easy run-in.'
Fly-half Ronan O'Gara also emphasised his Lions credentials with a man-of-the-match kicking display, bagging 14 points.