The 25-year old Bowe has scored 18 tries in 34 outings with the Welsh region since joining from Ulster in the summer of 2008. Included in that total is nine tries in his last 10 games.
The all-time leading try scorer in the Magners League with 35 tries, Bowe says he is delighted to be staying in Wales.
"The Ospreys coaching staff, combined with the rugby programme in place at the club, are helping me to fulfill my potential. I also feel that as a team we are on the cusp of something special and I want to be part of it," said Bowe.
"From an international perspective, the Ospreys have been the platform for much of the rugby success I have enjoyed over an unbelievable last 18 months As a result of that I feel a strong sense of loyalty to them.
"I was flattered by the interest from other European clubs but, after taking advice from my agent, family and friends, it all came back to the fact that I am enjoying my rugby and life in general at the Ospreys.
"A return to Ireland had a strong emotional pull and I take enormous pride in the privilege of wearing the Irish jersey. With a father from Munster and a mother from Leinster, who are both season ticket holders at Ulster, you can imagine the thorough family discussions about the merits of returning to play in Ireland.
"But I just feel all the ingredients are here for long-term success. I'm very excited about what we can achieve in the next three years.
"I love the way we play rugby here at the Ospreys and I'm excited about being involved in the Christmas derby games and upcoming crucial Heineken Cup fixtures."