But the three time Lions tourists has dismissed the notion that he has already decided his future and remains open minded.
"I said it because I was asked the question. I hadn't intended causing a stir," the 34-year-old centre told the BBC.
"The situation will unfold. I'll have to listen to my body.
"I haven't really allowed myself to think about it. If you start thinking about retirement in six months' time you're already there.
"I just want to concentrate on my rugby and enjoy it and live in the moment. It will all evolve.
"There are lots of factors, not just me, that come into those decisions.
"I haven't been wondering if Saturday will be the last time I'll play England in the Aviva Stadium, far from it."
O'Driscoll, who is targeting a fourth Lions tour, produced a sublime man-of-the-match performance against the Welsh last week.
The Leinster star created and scored a try in the victory but reckons his form will not have a bearing on his future.
"It hasn't altered my thinking," added O'Driscoll.
"Maybe when the time comes I'll look back on previous performances but a huge amount of it is about listening to your body.
"Games like last weekend take a long time to recover from when you're a little bit older.
"It's the cumulative effect as well. If you're lucky enough to play five Six Nations games in seven weeks that has a huge knock-on effect.
"I'm at game two, feeling OK and looking forward to England."