Wing Digby Ioane, back row Scott Higginbotham and lock Sitaleki Timani have all been withdrawn less than 12 hours after The Lions began their 10-match Tour with an eight-try win over the Barbarians in Hong Kong.
All three were expected to play a major role in the coming weeks but are now at long odds to feature in any part of the mouth-watering series in Brisbane, Melbourne and Sydney.
Higginbotham dislocated his shoulder when captaining the Rebels to a 33-20 defeat at the Reds yesterday; Timani suffered a dislocated thumb playing for the Waratahs against the Crusaders on Friday night; and Ioane is struggling with a knee problem that had already threatened to rule him out of the opening rubber at Suncorp Stadium on June 22.
Blindside flanker Higginbotham had been in superb form for his new franchise so far this term after featuring in 12 of his country's 15 Tests last year, while Timani's physicality was being talked of as a key factor in the forward battle with The Lions.
Ioane has long since established himself as the Qantas Wallabies' first-choice wing but is battling to recover quickly enough from minor surgery, although he will at least remain in camp in the hope that he will progress under the watchful eye of the national medical staff.
"Digby is unable to train," said Deans, who has called up scrum-half Nick Phipps instead of a fellow wing to replace Ioane.
"His focus is on getting his knee right, which is why we've chosen to bring him in anyway, so our medical staff can oversee the process.
"His absence from training opened up the opportunity to add another player. Nick (Phipps) has been playing well, has background with us through his experience last year and is a player who was always in our thoughts."
Phipps' call up is being seen by some - including the No9 himself - as a surprise given the form of Brumbies' rival Nic White but, with Deans having previously named Will Genia as his only scrum-half, there could yet be a further addition to that department on June 11 when six more players will join the party.
"Nick proved last year that he had the qualities to make a difference in the Test arena," added Deans.
"He was called on at a time of great adversity and responded. His work rate makes a big difference to those around him, as does his enthusiasm both on and off the field.
"Pleasingly, he has taken the benefits of his experience from last year back to the Rebels and added to them. He has been a point of difference player for the team this year and one of the leaders within their group."
Waratahs second row Kane Douglas and versatile Force back row Ben McCalman are the other men called up as replacements, with Douglas deemed unfortunate to miss out first time around and McCalman beginning to show the form that made him an international regular prior to arm and shoulder setbacks last season.
Revised 25-man Qantas Wallabies squad
Ben Alexander, Adam Ashley-Cooper, Berrick Barnes, Nick Cummins,Dave Dennis, Kane Douglas, Saia Fainga'a, Israel Folau, Will Genia, Liam Gill, Michael Hooper, Rob Horne, James Horwill, Sekope Kepu, Christian Leali'ifano, Ben McCalman, Stephen Moore, Ben Mowen, James O'Connor, Wycliff Palu, Nick Phipps, Benn Robinson, Rob Simmons, James Slipper, Joe Tomane