British & Irish Lions scrum-half Mike Phillips has been dropped for the clash and Warburton, who skippered the successful tour to Australia this summer, admits that complacency is not an option when representing your country.
"I don't think anybody should feel safe in a Welsh jersey," said Warburton.
"The message from the coaches is play every Welsh game like it could be your last.
"So I don't think anybody should feel safe in a Welsh jersey, which is the best way to be.
"You want to go out playing with a little bit of that nervousness and a bit of fear, really, because that's what brings you out.
"When you get backed into a corner you should come out fighting and I think that's the way all players should respond."