Peel is battling to overcome a shoulder injury, suggesting Phillips will get the nod from new Wales coach Warren Gatland when the line-up is unveiled.
And although Wales last won at Twickenham in 1988 - seven months before Phillips' sixth birthday - the 6ft 3in scrum-half mirrors a feelgood factor generated by Gatland since his arrival from New Zealand.
Phillips said: "It will be tough on Saturday, and we have to step things up, but we have the personnel to do it.
"All the boys seem to be a lot more focused. It is high intensity, and there is no room for slacking - it is up to us now.
"It would be great to be part of a winning team, and there is no reason why we can't go up there and win.
"The boys are full of confidence individually, as well as a team, for this game.
"In terms of the tournament, I think we can surprise a lot of people. The team has had a lot of experience from the World Cup, and it is still young and still moving forward."
If Peel is ruled out, then Phillips will need to play a major role if Wales are to end their Twickenham drought.
Although 28 caps into his Test career, many judges feel he has not yet fulfilled rich promise that first surfaced as Wales Under-21 captain.
Phillips added: "We all want to be number one, but you have to take steps to get there.
"I certainly have the ability to be there, and it is a case of when I get my opportunity I have got to take it and prove to people I am good enough to be there."
Wales continued their preparations under Gatland having spent the weekend at their rural training base while England players endured a gruelling round of Guinness Premiership action.
Areas for selection debate include second-row and back-row, where the anticipated partnerships are Ospreys pair Alun-Wyn Jones and Ian Evans at lock, with Jonathan Thomas packing down at number eight alongside flankers Ryan Jones and Martyn Williams.
Gatland is set to name five Ospreys among his back division - Phillips, fly-half James Hook, centre Gavin Henson, wing Shane Williams and full-back Lee Byrne.
Seasoned campaigner Stephen Jones is poised to miss out behind Hook, being named among the replacements, but he underlined the positive mood generated by Gatland's arrival.
Jones said: "Things have been very organised and very thorough.
"The structure of the week has been different, with shorter, but more intense, training sessions.
"We have been raising the bar in training, and we have to make sure we continue to do that. I believe we are going in the right direction."