And it could not have happened at a worse time, given that he would have headed the queue to replace World Cup hero Jonny Wilkinson, who was ruled out of the tournament because of a shoulder problem.
"Charlie's knee is improving now after his cartilage operation, but I think we are still about a month away," said Sharks coach Jim Mallinder.
England have three RBS 6 Nations games next month - against Ireland, Wales and France - and conclude their campaign in Paris on March 27.
In the absence of Wilkinson and Hodgson, Northampton's Paul Grayson has reclaimed the England number 10 jersey.
He produced outstanding performances in the away wins against Italy and Scotland, collecting 35 points to move him within eight of 400 for his country.