He has already drafted in Cardiff Blues prop Ben Evans as tighthead cover, but could start with Gethin Jenkins, who has been used as an impact substitute before half-time in the last five internationals.
And in the centre he has a selection dilemma with Mark Taylor, Tom Shanklin and Jamie Robinson all staking a claim for a place.
But despite the 36-15 defeat against Ireland last month Hansen claims there will not be a knee-jerk reaction beyond the need to change personnel because of injury.
The only players who might come into the equation on merit are scrum-half Dwayne Peel, who is pushing Gareth Cooper for his place, and lock Michael Owen.
"I don't think we will be making sweeping changes, though we will have to make one or two because of the injuries," said Hansen, who will unveil his side on Wednesday night.
"In the centre we are fortunate we have Mark Taylor, Tom Shanklin and Jamie Robinson all in good form at the moment. The selection will be about what we want to do technically.
"Ben (Evans) is in good form and that is always the first marker, and he has been here before. He is used to the system and it is no hassle for him to fit in.
"Ben is a good hard worker who is a strong scrummager on his day. He will be a great asset and be a presence at the contact area for at least an hour of the game. If he does that on Sunday, he will be a big plus."