They out-scored France three tries to one and even had an opportunity to pinch at least a draw in the final stages but lost the ball in contact.
And O'Driscoll clearly felt the pain of such an agonising loss in a game that was well within Ireland's reach.
"The guys have to go back and look at their individual performances," said O'Driscoll.
"You are going to have to up your game or be replaced. They're the blunt facts of the matter.
"We have a very good squad and if you don't produce performances, there's someone there. It's about fronting up or the possibility of missing out."
"We had a chance, three minutes to go, down in their green zone, 10 yards from the line; they were scrambling and we coughed up the ball."
"We coughed up ball too easily. The big thing is that when we scored tries, we took them through a number of phases.
"But when you turn it over after three or four it is so difficult to get any momentum. The chance was definitely there for us to take it and we didn't. That is a bitter pill to swallow."
O'Driscoll will be hoping his side can bounce back when they visit Murrayfield in two week's time to face Scotland, themselves hurting from their own loss at the hands of Wales.