"Our medical team have worked tirelessly as ever but Max is not quite right for the rigours of a Test match," said Scotland head coach Andy Robinson.
"We wish him a speedy recovery. Nikki has been part of our squad throughout the championship and played in our last Murrayfield international against Ireland.
"This is a golden opportunity for him now to produce a special performance.
"We approach tomorrow with confidence and determined to give the Murrayfield crowd a lot to cheer about."