Sale Sharks have suffered yet another injury blow with the loss of their Samoan centre Elvis Seveali'i for at least three months.
Seveali'i damaged his shoulder playing for the Pacific Islanders against Ireland in Dublin two days ago, and joins a lengthy Sharks casualty list.
England fly-half Charlie Hodgson and Scotland flanker Jason White will not play again this season due to serious knee injuries suffered during the autumn Test schedule.
Hodgson's England colleague Andrew Sheridan, meanwhile, sustained a fractured ankle and ligament damage during the victory over South Africa earlier this month, and could also be sidelined until next term.
On top of the injuries, prop Ben Evans is absent until December 19 while he serves a three-week ban after being cited for stamping.