Glasgowfly-half Duncan Weir claimed 20 points as he kicked three conversions, three penalties and crossed for one of four Scottish tries.
Michael Bradley's men dominated almost every aspect of an incredibly one-sided encounter at Netherdale to give Scottish fans a perfect start to the weekend.
"The boys were determined to beat England and they went about their business very well," said Bradley, who has already led Edinburgh to the Heineken Cup quarter-finals this term.
"We had six Glasgow Warriors in the pack and that gave us a big advantage.
"It was a good day at the office and it was nice to come here so close to the home of the late Bill McLaren. I am sure that he would have been proud of us."
The Saxons headed north having beaten the Irish Wolfhounds 23-17 at Sandy Park in Exeter last Saturday but they were well and truly outplayed by a Scotland side featuring a mix of experienced internationals and promising youngsters.
Scotlandled 13-0 at half-time courtesy of a stunning 60-metre score from Glasgow full back Stuart Hogg and a conversion and two penalties from man-of-the-match Weir before running riot after the break.
Weir was the first try scorer in the second period, with Gloucester scrum-half Rory Lawson and Edinburgh wing Matt Scott then crossing within five minutes of each other as Leicester lock Ed Slater was sent to the sin bin.
Slater's yellow card was the Saxons' second of the match following skipper James Gaskell's 37th-minute infringement but John Callard's troops were second best even when they kept 15 men on the field.
Scotland A: Hogg; Brown, Grove, Scott, Danielli; Weir, Lawson; Welsh, Hall, Kalman, Harley, Ryder, McInally, Fusaro, Vernon
Replacements: Grant for Kalman (53), Wilson for Ryder (53)
Not Used: MacArthur, Pyrgos, Godman, Murchie
England Saxons: Abendanon; Monye, Joseph, Twelvetrees, May; Lamb, Spencer; Wood, Brooker, Doran-Jones, Slater, Robson, Gaskell, Saull, Johnson
Replacements: Burns for Lamb (41), Benjamin for Spencer (57), Gray for Brooker (71), Myall for Robson (44)