Stuart Lancaster started with four different centres in their quartet of matches, Brad Barritt consistent throughout and joined by Kyle Eastmond, Owen Farrell and Billy Twelvetrees.
England fell to New Zealand and South Africa but recovered to defeat Samoa and Australia and face a big year in 2015 with the World Cup landing on British shores in September.
And O'Driscoll insists the player he joined on the British & Irish Lions' successful tour to Australia in the summer of 2013, Tuilagi, is imperative to England's cause.
"It's not ideal a year out of the World Cup not being sure who your ten is. You'll imagine that he will back George Ford now going into the Six Nations and he's been messing with the scrum-half as well.
"I think a really good foil for George Ford would be Eastmond and Manu. I think they could complement each other really well.
"I also really like Jonathan Joseph, but Eastmond has a nice subtlety. Luther Burrell is skilful for a big man, people look at him and think he can't play because he's sizey, but he can play plenty. I'd probably have to go with Eastmond."