With Chris Horsman already out for the whole championship and Adam Jones sidelined with a dead leg following the 47-13 hammering by England last weekend, Jenkins is in line for his first Wales start since last season's Grand Slam-sealing win against Ireland.
Jenkins came on at Twickenham but has had little rugby since returning from a shoulder operation following the Lions tour to New Zealand last summer.
He said: "I played there a bit on Saturday and I've played there one game this year for Cardiff, and the time before that was the British Lions' second game in the summer.
"I'm ready to play there. I played there last year and I'm starting to get used to it.
"My performance levels aren't anywhere near where they were last year and I'm disappointed with that but I've only played five games since coming back from injury and I wouldn't say I'm fully back into it yet.
"When you get injured it's a tough time training on your own and then when you recover you are expected to get straight back into it.
"I've had a couple of tough weeks with Cardiff Blues when we didn't perform, and I'm just looking forward to putting in some performances in the Six Nations."