The usual method of recovering from the blood clotting condition is simply rest, recuperation and medication - but getting back to full fitness can take up to six months.
And, with the start of the Rugby World Cup just six weeks away, the big number eight decided to embark on surgery normally reserved for patients with heart conditions.
So far, the procedure has been successful with Lyons confident of being fit for a tilt at winning back the Webb Ellis trophy.
"So far so good, I'm in a lot better position than I was," Lyons toldÂ Sydney'sÂ Daily Telegraph.
"This time last week I was a bit touch and go whether I would be right or not.
"We'll have a better idea how things are in the next two weeks. It was disappointing to miss the Bledisloe game, but hopefully I can get back on the park for the World Cup."
Lyons had a catheter inserted at the top of his groin to pump fluid into his arteries in his leg in an attempt to break down the clot in his calf and already the blood is starting to flow better.
"They never really do this on legs, they normally only do it on heart patients," explained Lyons.
"No one's ever really done it on the calf before.
"They usually just leave it because it heals itself. But that can take up to six months.
"I was a little bit sore afterwards but today I am feeling a lot better."
Lyons said he was confidentÂ ofÂ joining the Wallabies World Cup squad in camp in Sydney this week where he will compete with hard-running back-rower Wycliff Palu, who is making a speedy recovery from a shoulder injury, for a spot in Australia's starting XV.