Italy international Diego Dominguez will not be available for the match against Scotland in their last game of the RBS 6 Nations at Murrayfield.
The Stade Francais fly-half has not recovered from a bout of flu which also ruled him out of last weekend's match against France at the Flaminio stadium.
Rotherham fly-half Ramiro Pez will replace Dominguez. Flanker Mauro Bergamasco returns to the team after a thigh injury which forced him to miss last weekend's defeat.