England, who have not lost in Cardiff since 1993, head for the Welsh capital later this week with 11 survivors in their starting line-up from last season's record 50-10 victory at Twickenham.
Wales are still feeling the after-effects from a 30-22 defeat by Italy, and Wales coach Steve Hansen's team selection - scheduled for Thursday - is likely to show several changes, including the possibility of him naming a new captain.
Woodward, though, is taking nothing for granted as England look to complete the second stage of a possible 6 Nations Grand Slam.
"In any of these 6 Nations games, and I speak from a lot of experience here, if you get anything wrong, then you will lose," he said.
"I am sure that Wales will think they have got a lot to prove, having lost their first game. If you lose your first game in the 6 Nations, then the second is a must-win.
"We are under no illusions that it is going to be a tough game on Saturday. There will be no problem with our guys in terms of focusing on the game.
"We've got a lot of experience about losing games in the championship that we should have won."