And Wales coach Steve Hansen has confirmed the 23-year-old will not be considered to face England.
"Mark is not going to be playing," Hansen said. "Of the squad that went to Italy, he is the only one unavailable."
Full-back Rhys Williams is likely to feature on the wing, with Swansea's experienced Kevin Morgan taking over in the number 15 jersey.
Prop Martyn Madden, who is on the fringes of selection but did not make Hansen's squad in Italy, has narrowed the coach's front-row options as he continues his recovery from a shoulder injury.