Three of the changes are necessitated by injury, with Chris Paterson, Thom Evans and Jason White all ruled out.
Wings Simon Webster and Nikki Walker and back row players Alasdair Strokosch and Simon Taylor all earn starting spots, with Allister Hogg dropping out of the matchday 22 altogether.
Sale's Rory Lamont, who made his long-awaited return to international action against the Springboks, switches from wing to full back in place of Patterson, while Max Evans could win his first Scotland cap after being named among the replacements.
"There is an element of freshening up the squad and it's also an opportunity to look at certain blends ahead of the Six Nations but, as ever, the selection is about winning the game," said Hadden.
Scotland: Rory Lamont; Simon Webster, Ben Cairns, Nick De Luca, Nikki Walker; Phil Godman, Mike Blair (captain); Allan Jacobsen, Ross Ford, Euan Murray, Nathan Hines, James Hamilton, Alasdair Strokosch, John Barclay, Simon Taylor
Replacements: Dougie Hall, Alasdair Dickinson, Matt Mustchin, Scott Gray, Rory Lawson, Dan Parks, Max Evans