Mike Blair starts at scrum-half against Argentina with British & Irish Lions tourist Chris Cusiter on the bench.
The Edinburgh Gunners number nine impressed in place of Cusiter in the summer games against the Barbarians and Romania while the Border Reivers player was in New Zealand with Sir Clive Woodward's team.
Among the forwards, Dougie Hall is named as hooker to gain a second cap for his country.
And Glasgow Warriors lock Gavin Hamilton is also included in the starting XV.
Hall, Hamilton and centre Marcus Di Rollo will be making their first full Scotland appearances at Murrayfield after winning previous caps on foreign soil.
Now Hadden is aiming to build on the success of the three professional teams this season when the autumn Test series begins.
He said: "Argentina will represent a formidable challenge for us on Saturday.
"They are above us in the IRB world rankings and Scotland have not beaten the Pumas for 15 years.
"But I believe we approach this game in good heart and the fact that our three pro-teams amassed between them another 10-point haul in the Celtic League at the weekend means we can go into the contest with confidence.
"And I'd encourage as many supporters as possible to come to Murrayfield on Saturday to cheer us on."
Scotland team to play Argentina at Murrayfield:
Backs: Paterson (Edinburgh Gunners); Rory Lamont (Glasgow Warriors), Di Rollo (Edinburgh), Henderson (Glasgow), Sean Lamont (Northampton Saints); Parks (Glasgow), Blair (Edinburgh)
Forwards: Kerr (Leeds Tykes), D Hall (Edinburgh), Douglas (Border Reivers), Hamilton (Glasgow), Murray (Edinburgh), White (Sale Sharks), Taylor (Edinburgh); Hogg (Edinburgh).