The southern hemisphere players gained an important psychological advantage over their northern hemisphere counterparts ahead of the summer Lions tour, with a comprehensive win at Twickenham.
The galaxy of stars from the southern hemisphere sparkled with an eight-try command performance in the aid match for the Tsunami survivors.
The 40,246 crowd were treated to a competitive match in which the northern side, put together in the middle of the RBS 6 Nations championship, struggled to counter the class of the south - led by Australia's captain George Gregan.
All Black skipper Tana Umaga had his much anticipated appearance limited to just 22 minutes before he retired after taking a knock - but that was long enough for him to open the scoring with a 12th-minute try.
Australian full-back Chris Latham and Newcastle's Samoan Semo Sititi touched down twice each with their side's other tries coming from Samoan winger Brian Lima and the South African pair of flankers Schalk Burger and centre Jacque Fourie.
The pick of their tries was Sititi's first in the 51st minute when he applied the finish after Fijian winger Sireli Bobo's dazzling run split the North defence wide open for Latham to supply the final pass.
New Zealand fly-half Andrew Mehrtens produced a glittering kicking display, landing all his six conversions before Latham took over to kick the seventh.
The North replied with tries from England's second choice hooker Andy Titterrell, Worcester's former England flanker Pat Sanderson and French winger Mirco Bergamasco.
David Humphreys and Ceri Sweeney kicked a conversion each.