"We are confident both Joe and Toby will be fit. We have not been able to train too much this week but the session went well this morning and we are confident they will be fit," said Johnson.
Flood was replaced just before half-time on Sunday after landing awkwardly on his shoulder in the lead up to Worsley's try.
The Wasps flanker was substituted by second-row Nick Kennedy with 12 minutes of Sunday's game remaining and later had six stitches on a thumb wound.
England could finish as Six Nations runners-up if they beat Scotland and Ireland win the Grand Slam by defeating Wales in Cardiff.
England: Delon Armitage (London Irish); Ugo Monye (Harlequins), Mike Tindall (Gloucester), Riki Flutey (Wasps), Mark Cueto (Sale Sharks); Toby Flood (Leicester), Harry Ellis (Leicester); Andrew Sheridan (Sale Sharks), Lee Mears (Bath), Phil Vickery (Wasps), Steve Borthwick (Saracens, captain), Simon Shaw (Wasps), Tom Croft (Leicester), Joe Worsley (Wasps), Nick Easter (Harlequins). Replacements: Dylan Hartley (Northampton), Jason White (Leicester), James Haskell (Wasps), Nick Kennedy (London Irish), Danny Care (Harlequins), Andy Goode (Brive), Mathew Tait (Sale Sharks)