Wales welcome British & Irish Lions duo Gethin Jenkins and Dan Lydiate back into the starting XV for their Rugby World Cup quarter-final clash with South Africa.
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Meanwhile, Tyler Morgan is the only change in the backline and partners Jamie Roberts in midfield while George North returns to the left wing.
Alex Cuthbert will make his 40th Wales appearance in a back three alongside fellow British & Irish Lion North and full-back Gareth Anscombe.
Dan Biggar and Gareth Davies continue their half-back partnership with Biggar looking to add to his 2015 World Cup tally of 42 points.
Jenkins comes back into the starting XV to feature in his 18th World Cup match and he packs down alongside Scott Baldwin and Samson Lee.
Luke Charteris and Alun Wyn Jones continue in the second row with the latter making his 100th international appearance – 94th for Wales, plus six British & Irish Lions appearances.
Lydiate returns to the back row alongside captain Sam Warburton and Taulupe Faletau and head coach Warren Gatland is confident his side are ready for the battle to come against the Springboks.
"After coming through an incredibly tough pool, we are excited to be in the quarter-finals and returning to Twickenham," he said.
"The physicality and intensity of the matches so far will stand us in good stead for what is going to be a huge battle against the Springboks.
"They have grown game on game in this tournament and we know the challenge that faces us from a talented South African side."
Wales team to play South Africa:
15. Gareth Anscombe
14. Alex Cuthbert
13. Tyler Morgan
12. Jamie Roberts
11. George North
10. Dan Biggar
9. Gareth Davies
1. Gethin Jenkins
2. Scott Baldwin
3. Samson Lee
4. Luke Charteris
5. Alun Wyn Jones
6. Dan Lydiate
7. Sam Warburton (captain)
8. Taulupe Faletau
16. Ken Owens
17. Paul James
18. Tom Francis
19. Bradley Davies
20. Justin Tipuric
21. Lloyd Williams
22. Rhys Priestland
23. James Hook
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