The result extended the Red Roses’ Test match winning streak to a record 36 and also secured them a fifth consecutive Triple Crown in front of a delighted 26,247-strong crowd in Bristol.
Wales will take lots of positives from the clash, however, most notably the fact they ran in four tries of their own against the number one ranked side in the world to secure a bonus point.
Elsewhere, Ireland pushed France hard in their own back yard but eventually fell 26-7 while Scotland suffered a 41-14 loss away to Italy.
England march on
A debut try for Millie David and doubles from Meg Jones and Marlie Packer helped John Mitchell’s side to their third win of the tournament, but Wales can take heart from the attacking threat they showed during their trip across the River Severn.
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Maddie Feaunati got the ball rolling for England with the afternoon’s opening score before David crossed over on her home ground after being played in by Holly Aitchison's brilliant pass.
Fellow Bristol Bear Keira Bevan responded for the visitors when she opportunistically crossed the whitewash, while David’s afternoon was cut short after she failed a HIA.
England's bonus point was confirmed before the first half was out thanks to Packer and Jones; the latter putting on a show for the crowd with a superb solo effort.
Kelsey Jones powered over for Wales’ second try during the first half while Meg Jones, her namesake in white, completed her double in style by finishing off a brilliant team move.
The defending champions continued where they left off during the second half as Amy Cokayne helped herself to England’s sixth try.
Both wingers then got their names on the scoresheet as Claudia Moloney-MacDonald acrobatically finished in the left corner while Jess Breach strolled over on the opposite flank.
Packer completed her brace courtesy of a strong rolling maul and Maud Muir added try number 10 either side of the battling visitors adding two more to their tally through Gloucester-Hartpury duo Bethan Lewis and Seren Lockwood, to ensure Wales didn’t leave Bristol empty-handed.
Ireland push France
Ireland’s wait for a first win on French soil continues after finding themselves on the wrong side of the eventual scoreline at Stade Marcel-Michelin.
The clash was one that Ireland will have put a ring around on their calendar ever since they lost 18-13 to Les Bleues in their World Cup quarter-final last October.
The half-time scoreline read 7-7, but things could have been so different had Ireland not had three first-half tries ruled out by the TMO.
Cliodhna Maloney-MacDonald was frustrated to dot down two of them, but did also score one try that did stand.
However, France were too strong after the break as tries from Carla Arbez, Anais Grando and Lea Champon added to Ambre Mwayembe's first-half score, to keep their Six Nations hopes alive.
Scotland fall to Italy
Scotland fell to a second successive Six Nations defeat as Italy ran out 41-14 winners in Parma.
The hosts ran in five first-half tries, Alyssa D'Inca and Vittoria Zanette both scoring twice, to take a 29-0 lead into the interval.
Scotland hit back after the break with two tries from stand-in skipper Lana Skeldon, filling in in place of the injured Rachel Malcolm, and Molly Poolman, but Italy comfortably saw the game out to secure their first win of the tournament.
